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After an unexplained and unexpected explosion of the X-Mansion, Professor Charles Xavier and Jean Grey are missing. The X-Men disband and Scott begins to suffer from depression. One year later, the Mutant Response Division is imprisoning mutants. Emma Frost is able to locate a comatose Charles on Genosha in the care of Magneto. Professor X telepathically orders Wolverine to lead the X-Men and set out to save the world from The Sentinel Project and prevent the Brotherhood of Mutants from taking over the world before the future ends up dominated by Sentinels.